Impact of adipose-derived allogeneic mesenchymal stem cell transplantation on nociceptive reactions and gait parameters in rats with experimental peripheral neuropathy

Peripheral neuropathy is associated with chronic debilitating pain and difficult to treat. In this regard, the development of cell therapy neuropathic using adipose-derived mesenchymal stem cells (MSCs) seems be relevant. The work was devoted study impact allogeneic MSC transplantation on nociceptive reactions in response mechanical thermal stimuli gait parameters rats sciatic nerve injury. It found that a single local injection MSCs at dose 1·10 6 cells/kg eliminates axotomy-induced hyperalgesia 14th day after transplantation, contributes recovery functional index dynamic 7th prevents disturbances long-term period.